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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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With which product could tragacanth be replaced in a prescription containing 25 mg prednisolone disodium sulfate, 12 drops of opium tincture, 0.8 g tragacanth, 12 g sulfaguanidine, 15 g 5-aminosalicylic acid, and aqua up to 300 cc, with instructions to administer a 40 ml enema in the evening?
Is it possible to successfully prepare an AVA cream with a fat phase of only 30% as requested by a dermatologist?
What are the molar masses of copper gluconate and zinc gluconate for a prescription of 1 mg copper and 15 mg zinc, and what is the required amount for selenium-methionine, which is also listed without a quantity?
In the preparation of a mouthwash containing 0.5g tetracycline HCl, 0.2g lidocaine HCl, 0.1g vitamin A acetate (500,000 UI/g), 0.5g hydrocortisone base, and 3% mint water up to 100 ml, where vitamin A oil is solubilized with Tween 80 (8:1) and mint is replaced by bitter orange peel tincture for flavor, will tetracycline and lidocaine remain in solution while hydrocortisone is suspended? If not, should tetracycline be precipitated for better efficacy at a higher pH, and how would this affect lidocaine's solubility; furthermore, is the addition of xanthan gum useful for stabilization and viscosity, and how should the preparation be preserved given that Tween inactivates parabens?
How can metronidazole be brought into solution for a preparation of metronidazole in cold cream, and what is the cause of a slightly abrasive feeling on the skin if the cream is not sufficiently processed with an ointment mill?
What is the mechanism by which citric acid promotes the degradation of benzoyl peroxide, does this same mechanism apply to sodium citrate, and is it true that this degradation is likely not physically observable despite many shampoo bases containing one of these two substances?
What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?
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